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Tanzic (Tizanidine)

DESCRIPTION:
Tanzic (tizanidine hydrochloride) is a centrally acting α2-adrenergic agonist.
Tanzic is an agonist at α2-adrenergic receptor sites and presumably reduces spasticity by increasing pre synaptic inhibition of motor neurons. The effects of Tanzic (Tizanidine) are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce to reduce facilitation of spinal motor neurons.

COMPOSITION:
Each tablet contains:
Tizanidine Hydrochloride USP equivalent to Tizanidine … 2mg

THERAPEUTIC INDICATIONS:
Painful muscle spasms:
Associated with static and fuctional disorders of the spine (cervical and lumbar syndromes). Following surgery, e.g. for herniated intravertebral disc or osteoarthritis of the hip. Muscular spasms associated with accidental trauma.

Spasticity due to neurological disorders:
Like Multiple sclerosis, chronic myleopathy, degenerative spinal cord diseases, cerebrovascular accidents and cerebral palsy.

DOSAGE AND ADMINISTRATION:
For oral administration:
The effect of Tanzic (Tizanidine) on spasticty is maximum within 2-3 hours of dosing and it has relatively short duration of action. The timing and frequency of dosing should therefore be tailored to the individual and Tanzic (Tizanidine) should be given in individual doses, upto 3-4 times daily, depending on patient’s needs. There is considerable varaiation in response between patients so careful titration is necessary. Care should be taken not to exceed to dose producing the desired therapeutic effect. It is usual to start with the single dose of 2mg, increasing by 2mg increments at not less than half weekly intervals. The total daily dose should not exceed 36mg, although it is usually not necessary to exceed 24mg daily.

Mosic (Moxifloxacin)

DESCRIPTION:
Mosic (moxifloxacin hydrochloride) is a synthetic broad spectrum antibacterial agent and is available as Mosic Tablets for oral administration.

COMPOSITION:
Each tablet contains:
Moxifloxacin Hydrochloride USP equivalent to Moxifloxacin … 400 mg

THERAPEUTIC INDICATIONS:
Mosic tablets are indicated for the treatment of adults ( ≥ 18 years of age) with infections caused by susceptible strains of the designated microorganisms in the conditions listed below.

• Acute Bacterial Sinusitis
• Community Acquired Pneumonia
• Uncomplicated Skin and Skin Structure Infections caused by methicillin-susceptible
• Complicated Intra-Abdominal Infections Complicated Skin and Skin Structure Infections

DOSAGE AND ADMINISTRATION:
The dose of Mosic is 400 mg (orally) once every 24 hours. The duration of therapy depends on the type of infection as indicated:

Infection *	Daily Dose	Duration
Acute Bacterial Sinusitis	400 mg	10 days
Acute Bacterial Exacerbation of Chronic Bronchitis	400 mg	5 days
Community Acquired Pneumonia	400 mg	7-14 days
Uncomplicated Skin and Skin Structure Infections	400 mg	7 days
Complicated Skin and Skin Structure Infections	400 mg	7 – 21 days
Complicated Intra-Abdominal Infections	400 mg	5-14 days

* due to the designated pathogens

Kamcef (Cefixime)

DESCRIPTION:

COMPOSITON:
Kamcef capsules
Each capsules contains:
Cefixime Trihydrate USP equivalent to Cefixime …400 mg
Kamcef Suspension 100 mg/5ml, 200mg/5ml (30 ml suspension)

DESCRIPTION:
Kamcef (Cefixime) is a semi synthetic cephalosporin antibiotic for oral administration

MECHANISM OF ACTION:
As with other Cephalosporins, bactericidal action of Cefixime results from inhibition of cell wall synthesis.

INDICATIONS:
Kamcef (Cefixime) is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms

Otitis Media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella (Branhamella) catarrhalis, (most of which are beta-lactamase positive) and S. pyogenes

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis, caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains).

Uncomplicated gonorrhea (cervical/urethral), caused by Neisseria gonorrhoeae (penicillinase-and non-penicillinase- producing strains)

Velsaid (Flurbiprofen)

DESCRIPTION:
Each tablet contains 100 mg flurbiprofen. Flurbiprofen is a member of the phenylalkanoic acid derivative group of nonsteroidal anti-inflammatory drugs.

Flurbiprofen is a white or slightly yellow crystalline powder. It is slightly soluble in water at pH 7.0 and readily soluble in most polar solvents.

INDICATIONS:
Velsaid is a non steroidal anti inflammatory drug which possess analgesic, antipyretic and anti inflammatory properties and is indicated for:

• For relief of the signs and symptoms of rheumatoid arthritis
• For relief of the signs and symptoms of osteoarthritis

DOSAGE AND ADMINISTRATION:
After observing the response to initial therapy withFlurbiprofen (Velsaid), the dose and frequency should be adjusted to suit an individual patient's needs.

For relief of the signs and symptoms of rheumatoid arthritis or osteoarthritis, the recommended starting dose of Flurbiprofen (Velsaid) is 200 to 300 mg per day, divided for administration two, three, or four times a day. The largest recommended single dose in a multiple-dose daily regimen is 100 mg.

Ever-Alfa (Alfacalcidol)

DRUG DESCRIPTION:
Everalfa (Alfacalcidol) is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism.

COMPOSITION:
Each tablets contains 0.5 mcg Alfacalcidol.

INDICATIONS:
Everalfa (Alfacalcidol) is indicated in all conditions where there is a disturbance of calcium metabolism due to impaired 1-α hydroxylation such as when there is reduced renal function. The main indications are:

• Renal osteodystrophy
• Hyperparathyroidism (with bone disease)
• Hypoparathyroidism
• Neonatal hypocalcaemia
• Nutritional and malabsorptive rickets and osteomalacia
• Pseudo-deficiency (D-dependent) rickets and osteomalacia
• Hypophosphataemic vitamin D resistant rickets and osteomalacia
• Osteoporosis

DOSAGE & ADMINISTRATION:

Adults	1 microgram/day
Dosage in the elderly	0.5 microgram/day
Neonates and premature infants	0.05 - 0.1 microgram/kg/day
Children under 20 kg bodyweight	0.05 microgram/kg/day
Children over 20 kg bodyweight	1 microgram/day

The dose of Alfacalcidol should be adjusted thereafter to avoid hypercalcaemia according to the biochemical response.

Escam (Escitalopram oxalate)

DESCRIPTION:
Escitalopram oxalate is a potent selective serotonin reuptake inhibitor (SSRI). It is the active isomer of citalopram.

COMPOSITION:
Each film coated tablet contains: Escitalopram (as oxalate) …. 10 mg. Everest Specs

MODE OF ACTION:
Escitalopram is a Selective Serotonin Reuptake Inhibitor (SSRI) and belongs to a group of medicines known as antidepressants. These medicines help to normalize the levels of serotonin in the brain. Disturbances in the serotonin system of the brain are key factors in the development of depression and related disorders.

INDICATIONS:
It is used for the treatment of depression, generalized anxiety, social anxiety and panic disorders

DOSAGE:

Adults:
Depression: The usual dose is 10 mg per day. The recommended maximum dose is 20 mg per day.

Panic disorder: The starting dose is 5 mg per day for the first week.The dose may be increased to a maximum of 20 mg per day.

Elderly patients: The usual starting dose is 5 mg per day. It is recommended that the maximum dose is kept below 20 mg.

Patients with special risks: It is recommended that patients with liver disease receive an initial dose of 5 mg daily for the first two weeks which may be increased to 10 mg daily.

Children and adolescents (18 years): Escitalopram should not be given to children or adolescents (18 years).

PRESENTATIONS AVAILABLE:

It is available in the pack of 10 and 14 tablets.